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- 2021 -

A global view of standards for open image data formats and repositories.
Nature Methods, published
Jason R. Swedlow, Pasi Kankaanpää, Ugis Sarkans, Wojtek Goscinski, Graham Galloway, Leonel Malacrida, Ryan P. Sullivan, Steffen Härtel, Claire M. Brown, Christopher Wood, Antje Keppler, Federica Paina, Ben Loos, Sara Zullino, Dario Livio Longo, Silvio Aime & Shuichi Onami
Database Link  | Show Abstract 

The incidence of psoriasis in Chile: an analysis of the national Waiting List Repository.
Clinical and Experimental Dermatology, revised version submitted
Lecaros C, Dunstan J, Villena F, Ashcroft D, Parisi R, Griffiths C, Härtel S, Maul J, & Cruz C

RyR-mediated Ca2+ Release Induced by Neuronal Stimulation Participates in Nuclear Ca2+ Signal Generation, CREB Phosphorylation and Npas4 Expression.
Cell Calcium, revised version submitted
Lobos P, Córdova A, Vega-Vasquez I, Ramírez O, Adasme T, Toledo J, Cerda M, Härtel S, Paula-Lima A, & Hidalgo C

Salmonella Typhimurium triggers Extracellular Traps release in murine macrophages.
Frontiers in Cellular and Infection Microbiology, Accepted
Mónaco A, Canales N, Jara J, Härtel S, Chabalgoity A, Moreno M, Scavone P

Zebrafish Neural Crest: Lessons and Tools to Study In Vivo Cell Migration.
Epithelial-Mesenchymal Transition. Methods in Molecular Biology Series, The Epithelial-to Mesenchymal Transition. Editor: Humana, New York, NY, 79-106
Zain Alhashem, Macarena Alvarez-Garcillan Portillo, Ravinand Htun, Anton Gauert, Luis Briones Montecinos, Steffen Härtel, Claudia Linker
Database Link  | Show Abstract 

A Global View of Standards for Open Image Data Formats and Repositories.
Nature Methods, accepted
Swedlow J, Kankaanpää P, Sarkans U, Goscinski W, Galloway G, Malacrida L, Sullivan R, Härtel S, Brown C, Wood C, Keppler A, Paina F, Loos B, Zullino S, Longo D, Aime S, & Onami S

Una mirada a la cultura de datos en Chile - Desafíos y Lecciones de la Pandemia por COVID-19.
Submesa de Datos Covid-19, MinCiencia
Arancibia D, Araos R, Basso L, Bravo L, Guridi J, Härtel S, Jara J, Maass A, Marquet P, Mora S, & Pérez-Acle T
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- 2020 -

Eosinophils Control Liver Damage by Modulating Immune Responses Against Fasciola hepatica.
Frontiers in Immunology, section Microbial Immunology.
Sofía Frigerio, Valeria Da Costa, Monique Costa, María Florencia Festari, Mercedes Landeira, Santiago Rodríguez, Steffen Hartel, Jorge Toledo, Teresa Freire
Database Link  | Show Abstract 

dSTORM microscopy evidences in HeLa cells clustered and scattered ?H2AX nanofoci sensitive to ATM, DNA-PK, and ATR kinase inhibitors.
Molecular and Cellular Biochemistry
Liddle P, Jara-Wilde J, Lafon-Hughes L, Castro I, Härtel S and G Folle. 10
Database Link  | Show Abstract 

Mathematical Modeling for 2D Light--Sheet Fluorescence Microscopy image reconstruction.
IOPScience - Article ID: IP-102365.R1
Cueva Evelyn, Courdurier Matias, Osses Axel, Castañeda Victor, Palacios Benjamin, Härtel Steffen
Database Link  | Show Abstract 

Fibrinogen-clotting enzyme, pictobin, from Bothrops pictus snake venom. Structural and functional characterization.
International Journal of Biological Macromolecules.
Vivas-Ruiz DE, Sandoval GA, Gonzalez-Kozlova E, Zarria-Romero J, Lazo F, Rodríguez E, Magalhães HPB, Chávez-Olortegui C, Oliveira LS, Alvarenga VG, Urra FA, Toledo J, Yarlequé A, Eble JA, Sanchez EF
Database Link  | Show Abstract 

Optimising adjacent membrane segmentation and parameterisation in multi‐cellular aggregates by piecewise active contours.
Journal of Microscopy, 278(2):59-75.
Jorge Jara‐Wilde, Iván Castro, Carmen Gloria Lemus, Karina Palma, Francisca Valdés, Víctor Castañeda, Nancy Hitschfeld, Miguel L. Concha, Steffen Härtel
Database Link  | Show Abstract 

- 2019 -

Evaluating Online Consumer Medication Information Systems: A Comparative Online Usability Study.
Stefan Sigle, Pilar Barriga, Francisco Correa, Christian Juhra, Steffen Härtel, Christian Fegeler
Download PDF   | Database Link  | Show Abstract 

Predicting nationwide obesity from food sales using machine learning. Health Informatics Journal.
Jocelyn Dunstan, Marcela Aguirre, Magdalena Bastías, Claudia Nau, Thomas A Glass, Felipe Tobar.
Database Link  |

Chronic Fluoxetine Treatment Induces Maturation-Compatible Changes in the Dendritic Arbor and in Synaptic Responses in the Auditory Cortex
Estibaliz Mariela Ampuero, Mauricio Cerda, Steffen Hartel, Francisco Javier Rubio, Solange Massa, Paula Cubillos, Lorena Abarzua, Rodrigo Sandoval, Ursula Wyneken
Database Link  |

Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study.
Aesthetic Surgery Journal
Danilla SV, Jara RP, Miranda F, Bencina F, Aguirre M, Troncoso E, Erazo CA1, Andrades PR, Sepulveda SL, Albornoz CR.
Database Link  |

Prolonged wait time is associated with increased mortality for Chilean waiting list patients with non-prioritized conditions. BMC Public Health. 2019 Feb 26;19(1):233. doi: 10.1186/s12889-019-6526-6
Martinez DA, Zhang H, Bastias M, Feijoo F, Hinson J, Martinez R, Dunstan J, Levin S, Prieto D.
Database Link  |

Neuromuscular control during gait in people with haemophilic arthropathy
Cruz-Montecinos C, Pérez-Alenda S, Cerda M, Maas Huub. Haemophilia, 25(2):e69-e77
Database Link  |

Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate. Scientific Reports, 9(1):1835 (2019).
Araya C, Hakkinen H, Carcamo L, Cerda M, Savy T, Rookyard C, Peyriéras N, Clarke J.
Database Link  |

Does epimuscular myofascial force transmission occur between the human quadriceps muscles in vivo during passive stretching? Journal of Biomechanics, 83:91-96 (2019).
Freitas SR, Antunes A, Salmon P, Mendes B, Firmino T, Cruz-Montecinos C, Cerda M, Vaz JR.
Database Link  |

- 2018 -

Assessment of tensile mechanical properties of the Achilles tendon in adult patients with haemophilic arthropathy. Reproducibility study. Haemophilia, 25(1):e27-e29.
Cruz-Montecinos C, Pérez-Alenda S, Contreras-Sepúlveda F, Querol F, Cerda M, Maas H.
Database Link  |

Generation of a HER2 Breast Cancer Gold-Standard Using Supervised Learning from Multiple Experts.
Violeta Chang. Lecture Notes in Computer Science, vol 11043, pp 45-54, Springer, doi:10.1007/978-3-030-01364-6_6
Download PDF   | Show Abstract 

A high-speed tracking algorithm for dense granular media.
Cerda M, Navaro CA, Silva J, Waitukaitis SR, Mujica N, Hitschfeld N. Computer Physics Communications, doi:10.1016/j.cpc.2018.02.010.
Database Link  |

HER2 Overexpression Segmentation using Machine Learning Classifiers and Quasi-random Patches for Training Data Selection.
Raquel Pezoa; Luis Salinas; Claudio Torres; Steffen Härtel
Applied Intelligence, submitted

Variable Numbers of Calreticulin Genes in Trypanosoma Cruzi Correlate with Atypical Morphology and Protein Expression.
González A, Härtel S, Mansilla J, Sanchez-Valdez F, and Ferreira, A
Immunobiology, in press, ref IMBIO51736
Database Link  |

Evaluating the 2014 sugar-sweetened beverage tax in Chile: An observational study in urban areas.
Ryota Nakamura, Andrew J. Mirelman,Cristóbal Cuadrado,Nicolas Silva-Illanes,Jocelyn Dunstan,Marc Suhrcke - PLOS Medicine
Download PDF   | Database Link  |

Honored papers 2017: Gold-standard for computer-assisted morphological sperm analysis, Chang V, Garcia A, Hitschfeld N, Härtel S, Comput Biol Med. 2017 Apr 1; 83:143–150
Edward J. Ciaccio
In Press, Accepted Manuscript, Available online 18 May 2018

Honored Papers: Gold-standard for computer-assisted morphological sperm analysis. Computers in Biology and Medicine.
Edward J. Ciaccio
In Press, Accepted Manuscript, Available online 18 May 2018
Database Link  |

- 2017 -

Epigenetic Editing Of The Dlg4/Psd95 Gene Improves Cognition In Aged And Alzheimer's Disease Mice.
Bustos, Fernando J; Ampuero, Estibaliz; Jury, Nur; Aguilar, Rodrigo; Falahi, Fahimeh; Toledo, Jorge; Ahumada, Juan; Lata, Jaclyn; Cubillos, Paula; Henríquez, Berta; Guerra, Miguel V; Stehberg, Jimmy; Neve, Rachael L; Inestrosa, Nibaldo C; Wyneken, Ursula; Fuenzalida, Marco; Härtel, Steffen; Sena-Esteves, Miguel; Varela-Nallar, Lorena; Rots, Marianne G; Montecino, Martin; van Zundert, Brigitte.
Database Link  |

Interfering of the reelin/ApoER2/PSD95 signaling axis reactivates structural plasticity of mature hippocampal neurons.
Estibaliz Ampuero, Nur Jury, Steffen Härtel, María Paz Marzolo & Brigitte van Zundert
Journal of Cellular Physiology, Sep 21. doi: 10.1002/jcp.25605. [Epub ahead of print]
Database Link  | Show Abstract 

Chile's National Center for Health Information Systems: A Public-Private Partnership to Foster Health Care Information Interoperability.
Capurro D, Echeverry A, Figueroa R, Guiñez S, Taramasco C, Galindo C, Avendaño A, García A, Härtel S, doi:10.3233/978-1-61499-830-3-693
Stud Health Technol Inform, 245, 693-695.
Download PDF   | Database Link  |

Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway.
Maldonado H, Calderon C, Burgos-Bravo F, Kobler O, Zuschratter W, Ramirez O, Härtel S, Schneider P, Quest A, Herrera-Molina R & Leyton L
Biochim Biophys Acta. 2017 Feb;1864(2):243-254. doi: 10.1016/j.bbamcr.2016.11.006.

Sleep/wake disorders and the hypocretin/orexin system in a zebrafish model of Parkinson’s Disease.
Almudena Laliena Izquierdo, Victor Castañeda, Steffen Härtel, Miguel Concha
Mechanisms of Development 145, S128, doi.org/10.1016/j.mod.2017.04.352
Database Link  |

CDK5 downregulation enhances synaptic plasticity.
Rafael Andrés Posada-Duque, Omar Ramirez, Steffen Härtel, Nibaldo C Inestrosa, Felipe Bodaleo, Christian González-Billault, Alfredo Kirkwood, Gloria Patricia Cardona-Gómez
Cellular and Molecular Life Sciences 74(1), 153-172, doi.org/10.1007/s00018-016-2333-8
Database Link  |

Light/dark cycles modulate asymmetric parapineal connectivity to the left habenula in zebrafish larvae.
K Palma, M Meynard, V Cornejo, M Cerda, J Jara, S Härtel, M Concha
Mechanisms of Development 145, S122-S123, doi.org/10.1016/j.mod.2017.04.334
Database Link  |

Epigenetic editing of the PSD95 gene improves cognition in aged and Alzheimer's disease mice.
Bustos F, Ampuero E, Aguilar R, Jury Nur, Varela-Nallar L, Falahi F, Toledo J, Ahumada J, Lata Jaclyn, Cubillos P, Henríquez B, Guerra M, Stehberg J, Neve R, Inestrosa N, Wyneken U, Fuenzalida M, Härtel S, Sena-Esteves M, Rots Marianne, Montencino M and B van Zundert
Brain, a Journal of Neurology, published Nov 16, https://doi.org/10.1093/brain/awx272
Database Link  |

Asymmetric morphogenesis of the parapineal organ in the embryonic zebrafish brain
Lemus C, Palma K, Jara J, Härtel S and M Concha
Mechanisms of Developments, 145, 56, doi:10.1016/j.mod.2017.04.112.
Database Link  |

Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish.
German Reig, Mauricio Cerda, Néstor Sepúlveda, Daniela Flores, Victor Castaneda, Masazumi Tada, Steffen Härtel, Miguel Concha
Nature Communications, 10.1038/ncomms15431
Database Link  |

Automatic classification of human sperm head morphology.
Violeta Chang, Laurent Heutte, Caroline Petitjean, Steffen Härtel, Nancy Hitschfeld
Computers in Biology and Medicine, 84, 205–216
Database Link  |

RyR-mediated calcium release and mitochondrial ROS generation partake in the synaptic dysfunction caused by amyloid β peptide oligomers.
Carol SanMartin, Pablo Veloso, Tatiana Adasme, Alejandra Garcia, Steffen Hartel, Cecilia Hidalgo, Andrea C. Paula-Lima
Front. Mol. Neurosci., published Apr 25, doi: 10.3389/fnmol.2017.00115
Database Link  | Show Abstract 

Gold-standard for computer-assisted morphological sperm analysis.
Violeta Chang, Alejandra García, Nancy Hitschfeld & Steffen Härtel
Computers in Biology and Medicine, 84, 205–216
Database Link  |

Gastrulation in an annual killifish: Molecular and cellular events during germ layer formation in Austrolebias.
Luisa Pereiro, Felix Loosli, Juan Fernández, Steffen Härtel, Joachim Wittbrodt, & Miguel Concha
Developmental Dynamics, DOI: 10.1002/dvdy.24496
Database Link  | Show Abstract 

RyR2-mediated Ca2+ release and mitochondrial ROS generation partake in the synaptic dysfunction cause by amyloid B peptide oligomers. Frontiers in Molecular Neuroscience.
San Martin C, Veloso Pablo, Adasme T, Lobos P, Bruna B, Galaz J, García A, Härtel S, Hidalgo C and A Paula-Lima
Database Link  |

- 2016 -

Ultrasound assessment of fascial connec- tivity in the lower limb during maximal cervical flexion: technical aspects and practical application of automatic tracking.
Cruz-Montecinos C, Cerda M, Sanzana-Cuche R, Martin-Martin, J. BMC Sports Science, Medicine and Rehabilitation 8:18

Assessment of Automatically Exported Clinical Data from a Hospital Information System for Clinical Research in Multiple Myeloma.
Torres V, Cerda M, Knaup P, Lopprich M. Studies in Health Technology and Informatics 228:332-6.

Segmentation of HER2 protein overexpression in immunohistochemically stained breast cancer images using Support Vector Machines.
Raquel Pezoa, Luis Salinas, Claudio Torres, Steffen Hartel, Cristian Maureira-Fredes & Paola Arce
Journal of Physics: Conference Series 762 (2016) 012050 / doi:10.1088/1742-6596/762/1/012050
Database Link  | Show Abstract 

Directional asymmetry in the volume of the human habenula.
Ahumada P, Lemus C, Diaz E, Osorio-Reich M, Härte S and M Concha
Brain Structure and Function, 222(2), 1087-1092, DOI: 10.1007/s00429-016-1231-z
Show Abstract 

Leader cells define directionality of trunk, but not cranial, neural crest migration.
Richardson J, Gauert A, Briones L, Escudero L, Zainalabdeen A, Gorostiza E, Kabla A, Assar R, Härtel S & C Linker
Cell Reports, Cell Reports 15(9), 1-13
Show Abstract 

Fimbriae have distinguishable roles in Proteus mirabilis biofilm formation
Scavone P, Iribarnegaray V, Caetano A, Schlapp G, Hartel S, & Zunino P
Pathogens and Disease: 74(5). pii: ftw033. doi: 10.1093/femspd/ftw033. Epub 2016 Apr 17.
Show Abstract 

A frame-based ANN for classification of hyperspectral images: assessment of mechanical damage in mushrooms.
Rojas-Moraleda R, Valous N, Gowen A, Esquerre C, Härtel S, Salinas L, & C O'Donnell
Neural Computing and Applications (NCAA), pp 1-13, doi:10.1007/s00521-016-2376-7
Database Link  |

- 2015 -

In vivo relationship between pelvis motion and deep fascia displacement of the medial gastrocnemius: anatomical and functional implications.
Cruz-Montecinos C, Gonzalez A, Lopez D, Cerda M, Sanzana-Cuche R, Cuesta-Vargas A. Journal of Anatomy, 227(5):665-72.

Estimation of tensile properties of the Achilles tendon in haemophilic arthropathy of the ankle.
Cruz-Montecinos C, Perez-Alenda S, Oyarzun A, Cerda M, Querol F: Case Study. Haemophilia, 21(2):e141e143.

Translational cancer research comes of age in Latin America.
Investigators of the U.S. Latin America Cancer Research Network.
Science Translational Medicine, Vol. 7(319), pp. 319fs50. doi: 10.1126/scitranslmed.aad5859.
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Higher blood vessel density in comparison to the lymphatic vessels in oral squamous cell carcinoma.
Maturana-Ramírez A, Espinoza I, Reyes M, Aitken JP, Aguayo F, Hartel S, & G Rojas-Alcayag.
Journal of Clinical and Experimental Pathology, 8(10):13677-86
Show Abstract 

An Implementation of Combined Local-Global Optical Flow
Jara J, Cerda M, Delpiano J, and S Härtel
Image Processing On Line, 5 (2015), pp. 139�158.
Show Abstract 

Transactivation activity and nucleocytoplasmic transport of <beta>-catenin are independently regulated by its C-terminal end
Maturana J, Niechi I, Silva-Pavez E, Huerta-Castro H, Cataldo R, Härtel S, Barros F, Galindo M & J Tapia
Gene 573(1), 115�122. http://dx.doi.org/10.1016/j.gene.2015.07.039
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Trypanosoma cruzi Infectivity Assessment in 'in vitro' Culture Systems by Automated Cell Counting
Liempi A, Castillo C, Cerda M, Droguett D, Duaso J, Barahona K, Hernandez A, Luján C, Fretes R, Härtel S, Kemmerling U
Acta Tropica, 143:47-50. doi: 10.1016/j.actatropica.2014.12.006
Show Abstract 

Trypanosoma cruzi Calreticulin Topographical Variations in Parasites Infecting Murine Macrophages
González A, Valck C, Sanchez G, Härtel S, Mansilla J, Ramirez G, Fernandez S, Arias JL, Galanti N and Ferreira A
The American Journal of Tropical Medicine and Hygiene, 9, 92(5):887-97. doi: 10.4269/ajtmh.14-0497
Show Abstract 

- 2014 -

Bleomycin-induced yH2AX foci map preferentially to replicating domains in CHO9 interphase nuclei
Liddle P, Lafon-Hughes L, Di Tomaso MV, Reyes-Ábalos AL, Jara J, Cerda M, Härtel S and G Folle
Chromosome Research, CHRS-s-13-00133, DOI: 10.1007/s10577-014-9433-9
Show Abstract 

Gold-standard and improved framework for sperm head segmentation
Chang V, Saavedraa J, Castaneda V, Sarabia L, Hitschfeld N and S Härtel
Computer Methods and Programs in Biomedicine, DOI:10.1016/j.cmpb.2014.06.018
Show Abstract 

Computational Methods for Analysis of Dynamic Events In Cell Migration.
Castañeda V, Cerda M, Santibañez F, Jara J, Pulgar E, Palma K, Lemus CG, Concha M, Härtel S
Current Molecular Medicine, 14(2), 291-307.
Show Abstract 

Spermatozoa from mice deficient in Niemann-Pick disease type C2 (NPC2) protein have defective cholesterol content and reduced in vitro fertilising ability.
Busso D, Oñate-Alvarado MJ, Balboa E, Castro J, Lizama C, Morales G, Vargas S, Härtel S, Moreno RD and S Zanlungo
Reproduction, Fertility and Development, 26(4), 609-21. doi: 10.1071/RD12059
Show Abstract 

Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons.
San Martín CD, Paula-Lima AC, García A, Härtel S, Núñez MT and C Hidalgo
Frontiers in Molecular Neuroscience, 11, 7-13. doi: 10.3389/fnmol.2014.00013
Show Abstract 

Optimización y paralización de un algoritmo de generación de skeletons.
Ivan Rojas, Memoria de Titulo Para Ingeniero Civil en Computación. UF-Med/FCFM, Universidad de Chile, Santiago, Chile.
Tutores: Prof. N Hitschfeld, M Cerda and S Härtel

- 2013 -

A Comprehensive System for Facial Animation of Generic 3D Head Models driven by Speech
Terissi L, Cerda M, Gomez JC, Hitschfeld-Kahler N, and Girau B.
EURASIP Journal of Audio, Speech and Music Processing (Springer), 5, 5 doi:10.1186/1687-4722-2013-5
Show Abstract 

SOFI of GABAB neurotransmitter receptors in hippocampal neurons elucidates intracellular receptor trafficking and assembly. Proceedings of SPIE.
Huss A, Ramírez OA, Santibañez F, Couve A, Härtel S, Enderlein J. Proceedings of SPIE. Vol. 8590. doi: 10.1117/12.2006215

Stereo Time-of-Flight with Constructive Interference
Victor Castaneda, Diana Mateus and Nassir Navab
IEEE Transactions on Pattern Analysis and Machine Intelligence (Accepted)
Show Abstract 

Daam1 is an effector of asymmetric brain morphogenesis that regulates dendritic and axonal outgrowth in dorsal habenular neurons
Colombo A, Palma K, Armijo L, Mione M, Signore IA, Morales C, Guerrero N, Pérez R, Suazo J, Marcelain K, Briones L, Härtel S, Wilson SW, and M Concha
Development, 140, 3997-4007
Show Abstract 

Asymmetry in neural fields: a spatiotemporal encoding mechanism
Cerda M and Girau B
Biological Cybernetics Volume 107, Issue 2 (2013), Page 161-178 (Springer). doi:10.1007/s00422-012-0544-0 (Online)
Show Abstract 

- 2012 -

Ciencia Computacional Aplicada a la Biomedicina
Jara J, Histchfeld N, and Härtel S
further authors : Lemus C, Santibáñez F, Ramirez O, Concha M. Revista BITS de Ciencia, Departamento de Ciencias de la Computacion, Universidad de Chile, Issue 8, pp: 36-43
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TRP, TRPL and cacophony channels mediate Ca2+ influx and exocytosis in axonal terminals of Drosophila photoreceptors
Astorga G, Härtel S, Sanhueza M and J Bacigalupo
PLosOne, PLoS ONE 7(8): e44182. doi:10.1371/journal.pone.0044182
Show Abstract 

Generación de skeletons a partir de mallas de superficie
Liliana Alcayaga, Memoria para: Ingeniero Civil en Computación, F-Med/FCFM, Universidad de Chile, Santiago, Chile. Tutores: S Hartel (F-Med) / N Hitschfeld (DCC/FCFM)
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Performance of optical flow techniques for motion analysis of fluorescent point signals in confocal microscopy
Delpiano J, Jara J, Scheer J, Ramírez O, Ruiz-del-Solar J and S Härtel
Machine Vision and Applications, Volume 23, Issue 4, pp: 675-89
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Caveolin-1-Enhanced Motility and Focal Adhesion Turnover Require Tyrosine-14 but not Accumulation to the Rear in Metastatic Cancer Cells
Urra H, Torres V, Ortiz R, Lobos L, Díaz M, Díaz N, Härtel S, Leyton L, and A Quest
PLosOne, Volume 7, Issue 4, e33085, 1-14
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A Method for Analysis of Lipid Vesicle Domain Structure from Confocal Image Data
Husen P, Fidorra M, Härtel S, Bagatolli L, and J Ipsen
European Biophysics Journal (EBJO), 41(2): 161-75
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- 2011 -

Microtubule-associated protein 1B (MAP1B) is required for dendritic spine development and synaptic maturation
Tortosa E, Montenegro-Venegas C, Benoist M, Hartel S, Gonzalez-Billault C, Esteban J and J Avila
J Biol Chem. 286(47), pp 40638-48. doi: 10.1074/jbc.M111.271320
Show Abstract 

Development of 3D Architecture of Uropathogenic Proteus mirabilis Batch Culture Biofilms - A Quantitative Confocal Microscopy Approach -
Schlapp G, Scavone P, Zunino P and S Härtel
J Microbiol Methods, 87(2) : 234-40
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Changes in Rab3D expression and distribution in acini of Sjögren's Syndrome patients is associated to loss of cell polarity and secretory dysfunction
Bahamondes V, Albornoz M, Aguilera S, Alliende C, Molina C , Castro I, Urzua U, Quest A, Barrera M, González S, Sanchez M, Härtel S, Hermoso M, Leyton C & González M
Arthritis & Rheumatism, 63(10): 3126�3135

Association of age with sperm DNA fragmentation
Aumento del daño en el DNA espermatico en varones mayores de 40 años.
Horta F, Madariaga M, Garcia A, Härtel S & Smith R
Revista Médica de Chile, 139: 306-312
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Location matters: the endoplasmic reticulum and protein trafficking in dendrites.
Ramirez O, S Härtel & Couve A
Biological Reseach 44: 17-23
Show Abstract 

High-frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-mediated Ca2+ Release and Generates Hydrogen Peroxide, which Jointly Stimulate NF-kB Activity
Riquelme D, Alvarez A, Leal N, Adasme T, Espinoza I, Valdés JA, Troncoso N, Härtel S, Hidalgo J, Hidalgo C, & MA Carrasco
Antioxid Redox Signal. 14(7):1245-59
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- 2010 -

Confined Displacement Algorithm Determines True and Random Colocalization in Fluorescence Microscopy
Ramirez O, García A, Rojas R, Couve A & S Härtel
Journal of Microscopy, Sep 1;239(3):173-83
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The action of sphingomyelinase in lipid monolayers as revealed by microscopic image analysis
Fanani ML, Härtel S, De Tullio L, Jara J, Olmos F, Oliveira R & B Maggio
Biochimica et Biophysica Acta (BBA) - Biomembranes Volume 1798, Issue 7, 1309-1323
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Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ.
Oteiza P, Koeppen M, Krieg M, Pulgar E, Farias C, Melo C, Preibisch S, Müller D, Tada M, Hartel S, Heisenberg CP, & M Concha
Development, 137:3459-68
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Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by deep etching electron microscopy.
Cárdenas C, Escobar M, García A, Osorio-Reich M, Härtel S, Foskett JK, Franzini-Armstrong C.
J Struct Biol. 171 (3):372-381
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- 2009 -

Lipid domains in giant unilamellar vesicles and their correspondence with equilibrium thermodynamic phases: A quantitative fluorescence microscopy imaging approach.
Fidorra M, Garcia A, Ipsen J, Härtel S & L Bagatolli.
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1788(10):2142-9. [Epub 2009 Aug 21]
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Insulin Resistant Skeletal Muscle: Mitochondria Structure, Dynamics And Calcium Homeostasis.
Verónica S Eisner, Alejandra García, Steffen Härtel, Matías Escobar, Mariana Casas, Paola Aedo, David Mears, Marcelo Ezquer, Paulette Conget, Sergio Lavandero, Cecilia Hidalgo, Enrique Jaimovich
Biophysical Journal, 96(3), 235a, dx.doi.org/10.1016/j.bpj.2008.12.1157
Database Link  |

Segmentación de Objetos en Imágenes de Microscopia mediante Contornos Activos con Adaptabilidad Topológica.
Felipe Olmos, Memoria para: Ingeniero Civil en Computación, F-Med/FCFM, Universidad de Chile, Santiago, Chile.
Tutores: S Hartel (F-Med) / A Maass (CMM/FCFM) / N Hitschfeld (DCC/FCFM)
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Dendritic Assembly of Heteromeric Gabab Receptor Subunits in Hippocampal Neurons.
Ramirez O, Vidal R, Tello J, Vargas K, Kindler S, Härtel S & A Couve.
J Biol Chem. May 8;284(19):13077-85. [Epub 2009 Mar 10]
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SMase-induced domain growth and shape relaxation driven by a rate-dependent, out-of-equilibrium, compositional change.
Fanani ML, De Tullio L, Härtel S, Jara J & B Maggio.
Biophysical Journal 96, pp: 67-76. [Epub 2008 Oct 10].
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NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells.
Espinosa A, Garcia A, Härtel S, Hidalgo C & E Jaimovich.
JBC. 284, pp:2568-2575. [Epub 2008 Nov 20]
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- 2008 -

Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.
Parra V, Eisner V, Chiong M, Criollo A, Moraga F, Garcia A, Härtel S, Jaimovich E, Zorzano A, Hidalgo C & S Lavandero.
Cardiovasc Res. 77(2), pp:387-97. [Epub 2007 Oct 4]
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Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: possible role in cardioprotection.
Sánchez G, Escobar M, Pedrozo Z, Macho P, Domenech R, Härtel S, Hidalgo C, Donoso P.
Cardiovasc Res., 77(2), pp:380-6. [Epub 2007 Sep 18]
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- 2007 -

Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport.
Vidal RL., Ramírez OA., Sandoval L., Koenig-Robert R., Härtel S. and Couve A.
Molecular and Cellular Neuroscience, 35(3):501-12.
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The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers.
De Tullio L., Maggio B., Härtel S., Jara J. & Fanani ML.
Cell Biochemistry and Biophysics 47, pp:169�177.
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3D Morpho-Topological Analysis of Asymmetric Neuronal Morphogenesis in Developing Zebrafish. Computational Modelling of Objects Represented in Images. Fundamentals, Methods and Applications.
S. Härtel, J. Jara, C.G. Lemus, M.L. Concha
Ed. João Manuel Tavares & Jorge Nata, Taylor and Francis Group, ISBN: 9780415433495, pp: 215-220.
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- 2006 -

Contornos activos en tres dimensiones para la segmentación de estructuras biológicas.
Jorge Jara Wilde, Proyecto de Titulo: INGENIERO CIVIL EN INFORMÁTICAINFORMÁTICA, Universidad Austral de Chile, Valdivia, Chile.
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Surface-bound phosphatase activity in ectomycorrhizal fungi: a comparative study between a colorimetric and a microscope-based method.
Alvarez M., Godoy R., Gieseke A., & Härtel S.
Biology & Fertility of Soils 42(6), 561-568, doi.org/10.1007/s00374-005-0053-6
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ATP steal between cation pumps: a mechanism linking Na+ influx to the onset of necrotic Ca2+ overload.
Castro J, Ruminot I, Porras OH, Flores CM, Hermosilla T, Verdugo E, Venegas F, Hartel S, Michea L & Barros LF.
Cell Death & Differentiation 13, pp:1675�1685.
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- 2005 -

Shape Transitions and Lattice Structuring of Ceramide-Enriched Domains Generated by Sphingomyelinase in Lipid Monolayers.
Härtel S., Fanani M.L., & Maggio B.
Biophysical Journal 88(1), pp: 287-304.
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Anatomical-physiological determination of surface bound phosphatase activity in ectomycorrhiza of Nothofagus obliqua based on image processed confocal fluorescence microscopy.
Alvarez M., Godoy R., Heyser W., & Härtel S.
Soil Biology and Biochemistry 37(1), pp: 125-132.
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Identification and classification of di- and triploid erythrocytes by multi-parameter image analysis: a new method for the quantification of triploidization rates in rainbow trout (Oncorhynchus mykiss).
Härtel S., Rojas R., Räth C., Guarda M.I., & Goicoechea O.
Archivos de Medicina Veterinaria XXXVII (2), pp: 147-154.
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- 2004 -

Surface bound phosphatase activity in living hyphae of ectomycorrhizal fungi of Nothofagus obliqua.
Alvarez M., Godoy R., Heyser W., & Härtel S.
Mycologia 96(3), pp: 479 - 487.
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Ultraviolet exposure of thymocytes: wavelength selective inhibition and induction of apoptosis.
Ojeda F., Guarda M.I., Lovengreen C., Hidalgo A., Folch H., Härtel S., & Maldonado C.
International Journal of Radiation Biology 80(6), pp: 445-450.
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- 2003 -

Staurosporine-Induced Apoptosis in Human Cornea Epithelial Cells In Vitro.
Härtel S., Zorn-Kruppa M., Tykhonova S., Alajuuma P., Engelke M., & Diehl H.
Cytometry 08, pp: 15-23.
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Ceramide Modulates the Lipid Membrane Organization at Molecular and Supramolecular Levels.
Carrer D., Härtel S., & Maggio B.
Chemisty and Physics of Lipids 122, pp: 147-152.
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New Perspectives in the Determination of phoshatase activity in ectomycorrhiza of Nothofagus obliqua in forests of southern Chile.
Alvarez M., Härtel S. Godoy R., & Heyser W.
Gayana 60(1), pp: 41-46.
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- 2002 -

The Susceptibility of Non-UV Fluorescent Membrane Dyes to Dynamical Properties of Lipid Membranes.
Härtel S., Tykhonova S., Haas M., & Diehl H.
Journal of Fluorescence, 12, pp: 465-479.
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Bidirectional Control of Sphingomyelinase Activity and Surface Topography in Lipid Monolayers
Fanani M., Härtel S., Oliveira R., & Maggio B.
Biophysical Journal 83(6), pp: 3416-3424.
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Kinetics of apoptotic markers in exogeneously induced apoptosis of EL4 cells.
Jessel R., Haertel S., Socaciu C., Tykhonova S., & Diehl H.
Journal of Cellular and Molecular Medicine 6(1), pp: 82-92.
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- 2000 -

Carotenoids in 1,2-dipalmitoyl-sn-glycero-3-phosphoryl-choline liposomes: incorporation and effects on phase transition and vesicle size.
Socaciu C., Jessel R., Härtel S., & Diehl H.
Journal of Medical Biochemistry 4(2), pp: 71-82.
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- 1998 -

Methyl-b-Cyclodextrins and Liposomes as Water-Soluble Carriers for Cholesterol Incorporation into Membranes and Its Evaluation by a Microenzymatic Fluorescence Assay and Membrane Fluidity-Sensitive Dyes.
Härtel S., Diehl H., & Ojeda F.
Analytical Biochemistry 258(2), pp: 277-284.
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Cholesterol induced variations of membrane dynamics related to the induction of apoptosis in mouse thymocytes.
Härtel S., Ojeda F., & Diehl H.
International Journal of Radiation Biology 74(5), pp: 607-615.
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- 1996 -

Radiation induced membrane effects in thymocyte apoptosis.
Härtel S & HA Diehl
Progress in Biophysics and Molecular Biology, 65, 89.
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Universidad de Chile Conicyt Xperts Explora Centro de Estudios Científicos