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  Steffen Härtel

Steffen Härtel was born in Frankfurt (Ger) and studied physics at the University Johann Wolfgang von Goethe (Frankfurt), at the Universidad de Córdoba (Arg), at the Universidad Austral de Chile (Valdivia, Chile), and at the University of Bremen. He received fellowships of the DAAD and the Bremer Studienfonds. His PhD thesis was honored with summa cum laude and received the ´Bremer Studienpreis´ and the special award of the Bruker Daltonik GmbH. In 2000, he worked at the TZI (Center for Technology and Informatics, Bremen), financed by the DfG. Between 2001 and 2003, he received a Feodor Lynen Fellowship by the Alexander von Humboldt Foundation (Ger) in combination with a postdoctoral fellowship of CONICET and worked in Bruno Maggio´s lab at the CIQUIBIQ (Córdoba, Arg). In 2003, he joined Felipe Barros´ lab at the Centro de Estudios Cientificos (CECS, Valdivia, Chile) with a 3-year postdoctoral FONDECYT fellowship. Since 2006, he is leading the Laboratory of Scientific Image Processing (SCIAN-Lab) at the Medical Faculty of the University of Chile. Presently he is an investigator of the Biomedical Neuroscience Institute (BNI), funded by the Millennium Science Initiative in 2011, Sub-Director for investigation of the Instituto de Ciencias Biomédicas ICBM, founder of CEDAI SpA, Director of the first Chilean Center for Digital Pathology CPDAI, Director of the Center for Medical Informatics and Telemedicine (CIMT) and the National Center for Health Information Systems (CENS). Since 2017, he became a full professor of the University of Chile.

+56 9 9885 1801 (cel) ó +56 2 2978 6366 (fijo) ;   Steffen Härtel ;  

  Mauricio Cerda

Mauricio Cerda was born in 1982 in Temuco, Chile. He obtained the B.S. degree on 2006, and Computer Engineer degree on 2007, both from the University of Chile. In 2011 he obtained the Ph.D. degree on Informatique at the INRIA/Loria Laboratory, Université Nancy 2, France supervised by Prof. Bernard Girau in the Cortex Team. The main topics of his PhD thesis were bio-inspired motion detection and perception. Since 2012 he joined the SCIAN-Lab as FONDECYT postdoc working with Steffen Hartel at the Medicine Faculty, Universidad de Chile, Santiago, Chile, where he worked on the quantification of 2D/3D structure in microscopy images. In January 2015 he was appointed Assistant Professor at the same institution. Currently, he works on the quantification of 2D dynamics of microscopy and ultrasound medical images supported by his FONDECYT Iniciación project (2016-2019). He is a young researcher of the Biomedical Neuroscience Institute (BNI), and Subdirector of the Center for Medical Informatics and Telemedicine (CIMT) created in 2015.

+56 2 2978 9641 ;   Mauricio Cerda ;  

  Jocelyn Dunstan

Jocelyn Dunstan was born in 1985 in Santiago, Chile. She obtained her bachelor and master in Physics from the University of Chile, and a PhD in Applied Mathematics from the University of Cambridge, where she investigated fluid patterns in bacterial suspensions. Her career in Public Health started with a postdoctoral fellowship at the Johns Hopkins School of Public Health. From January 2017 she has a researcher position at the School of Public Health, University of Chile, and she was recently appointed adjunct professor at the Program of Anatomy and Developmental Biology. Her main research interests are the study of food patterns and obesity using machine learning methods, and the implementation of energy balance equations to predict body weight changes

+56 2 2978 9665 ;   Jocelyn Dunstan ;  

  German Reig

German Reig was born in 1976 in Argentina. He studied molecular biology at University of San Luis in Argentina and obtained the B.S in 2004. In 2012 he obtained the Ph.D degree on Biomedical Sciences at University of Chile working on developmental biology and using annual fishes as a model organisms. He is currently starting a post-doctoral training at SCIAN-Lab in which he will investigate the importance of cellular adhesion and contact inhibition of cell locomotion as a driving forces of tissue expansion.

+56 2 2978 6436 ;   German Reig ;  

- Post Docs -

  Karina Palma

PhD. Student in Biomedical Sciences, Faculty of Medicine, University of Chile. I am beginning my PhD studies holding a CONICYT PhD Scholarship. My fields of expertise are Inmunofluorescence, Confocal Microscopy, Cell Morphology and 3D image analysis. My interests are in brain development in the zebrafish epithalamus, and trying to understand the morphology and formation of an asymmetric structure, the Parapineal Organ (Ppo) using a 3D Morpho-Topological approach. Also, I am interested in creating informatics tools that allow us to see neuronal projections (axon and dendrites) and neuronal plasticity in the Ppo projections.

+56 2 2978 6436 ;   Karina Palma ;  

  Eduardo Pulgar

Biochemist, University Austral of Chile, Valdivia, Chile. I am starting a doctoral degree in Biomedical Sciences at the Faculty of Medicine, University of Chile holding a CONICYT PhD scholarship. I am involved in a research project that studies the migratory processes and organogenetic transformations of dorsal forerunner cells. We use an experimental method which combines cell biology, molecular biology, 4D confocal microscopy and image analysis. This 3D morpho-topological approach is applied to transgenic and mutant zebrafish strains.

+56 2 2978 6436 ;   Eduardo Pulgar ;  

  Violeta Chang

Violeta Chang was born in Trujillo, Perú. She obtained the B.S. degree and Computer Engineer degree on 2001, both from the National University of Trujillo. In 2006 she obtained the MSc. degree on Computer Science at the same university. In 2015 she obtained the Ph.D. degree on Computer Science at the University of Chile. Since March 2012 she joined the SCIAN-Lab to work on her PhD thesis under the supervision of Prof. Nancy Hitschfeld and Prof. Steffen Härtel. Recently, she was granted a three year postdoctoral fellowship in SCIAN-Lab financed by FONDECYT to generate biomedical gold-standards using supervised learning based on multiple experts.

+56 2 2978 9647 ;   Violeta Chang ;  

  Jorge Toledo

I am a biochemist (University of Chile). I have developed my expertise and interest in cell biology, confocal microscopy, and image analysis fields. Currently, I am a PhD student in the Molecular Biology, Cellular and Neurosciences program at the Faculty of Science, University of Chile. In my doctoral research project I study the traffic of proteins through the Endoplasmic Reticulum (ER), by means of micro-FRAPs, image processing, skeletonization. At this regard, my main aim is to generate and develop a mathematical model able to predicts how proteins are transported into the ER. This project is performed at BNI (Biomedical Neuroscience Institute) and SCIAN-Lab. (Couve-Lab)

+56 2 2978 6266 ;   Jorge Toledo ;  

  Victor Castañeda

Victor Castañeda was born in Caracas, Venezuela. He studied Electrical engineering at Universidad de Chile, Santiago, Chile, and obtained his B.S and engineer degree in 2004 and 2005 respectively. In 2012 he obtained his Dr.rer.Nat. degree on computer science at Technische Universität München, Munich, Germany, thanks to his DAAD-CONICYT scholarship, supervised by Dr. Prof. Nassir Navab leader of the chair of Computer Assisted Medical Procedures and Augmented Reality. Since March 2012, he joined to SCIAN-Lab, working with Steffen Härtel at the Medicine Faculty of Universidad de Chile, Santiago, Chile. The main topics of his Ph.D. thesis were the processing of endoscopic images and 3D sensors as Time-Of-Flight cameras and Microsoft Kinect. Currently he works processing spermiogram images at CEDAI, Light-Sheet microscopy and analysis of 2D/3D microscopic images.

+56 2 2978 6266; ;   Victor Castañeda ;  

  Flavia Guiñazu

Flavia Guiñazu was born in Argentina. She obtains both the Professor (1996) and BSc (1997) degree in Biology at the Universidad Nacional de San Luis (UNSL, Argentina). Then she did her MSc (2000) in Neuroscience and Cell Biology at the Universidad Austral de Chile (UACH, Chile) doing her research on midbrain- hindbrain development and hydrocephaly. Later Her MPhil in Molecular Neurology (2003) and Her PhD in Cellular and Molecular Neurology (2006) honored with Summa Cum Laude at King’s College (KCL, London) awarded with a European Commission Research Grant working on forebrain development. Between 2007 and 2010 she obtains a Career Development Fellowship and a National Parkinson`s Society Award as a post doc on her research on Parkinson Disease. Then she becomes a Clinical Researcher, FIRC (2012) at Institute of Clinical Research (ICR, London) and Neurologist (2014) as part of Modernizing Medical Careers (NHS, England). In parallel she becomes a Health Leader and Big Data Manager under Leadership development program at King's Fund (London) and Chatham House (England). Her works experience as Research associated, “Professor adjunto”, Senior Research and Medical Advisor in the following universities, Institutes and hospital: UACH, KCL, National Institute Medical Research (NIMR, London), Institut National de la Santé et de la Recherche Médicale (INSERM, France), ICR and Guy´s hospital. All together means that she is interested in the combination of Primary Research, Clinical Researcher and Medical knowledge as a multi-disciplinary approach for CNS disease treatment and prevention. Also in Global Health and “Big Data management”. Medical Advisor and researcher Scientific Image Analisys (SCIAN) – Subdirector of the Center for Medical Informatics and Telemedicine (CIMT) in “Personalized Medicine”

+56 2 2978 9640 ;   Flavia Guiñazu ;  

- PhD students -

  Felipe Santibañez

Civil Engineer in Electronics, University of Concepcion, Concepcion, Chile. He previously worked on Fondef projects related with haptic technology in the Faculty of Engineering, University of Concepción (UdeC). This year he began working at the Laboratory of Optical Tweezers in the Faculty of Physics of UdeC. He joined the SCIAN-Lab in September 2010 to support modeling, parallelization and optimization of algorithms within NEMO. His areas of expertise are haptic based applications, image processing, computer vision and HPC. His interests are in cutting-edge technologies based on or related to electronics and programming. Also, in physical and biological applications of ultrasonic radiation pressure, and in general, in the use of electronics and computing in applied science problems. In his spare time, he works with a couple of engineers at UdeC developing a tactile platform with accessibility purposes for impaired people.

+56 2 2978 6436 ;   Felipe Santibañez ;  

  Jorge Jara

Civil Engineer in Informatics, University Austral of Chile, Valdivia, Chile. PhD student, Department of Computer Sciences, University of Chile, Santiago, Chile. I joined the SCIAN-Lab as undergraduate student of computer sciences, working with variational/PDE based active contour models for 2D/3D segmentation and characterization of biological structures in confocal microscopy images. I am interested in reliable segmentation techniques based on mathematical-computational models. Currently I am working on my PhD research topic, related to models and methods for segmentation and dynamics characterization of 3D structures and complexes in time-lapse microscopy images.

+56 2 2978 6436 ;   Jorge Jara ;  

  Raquel Pezoa

I am Ph.D student in Computer Science at Universidad Técnica Federico Santa María (UTFSM), Valparaíso. In 2008, I obtained the Computer Engineering degree and Master in Computer Science, both from UTFSM. I have experience in the analysis of immunohistochemistry stained tissue images (IHC-images), working with Support Vector Machines for the classification of the structures of the IHC-images. Currently, I am interested in the automatic segmentation of cells having missing information (subjective contours or surfaces) and in the use machine learning techniques for cellular structures identification.

+56 2 2978 6266 ;   Raquel Pezoa ;  

  Alex Cordova

I was born on 1983, in Punta Arenas . I m a Biochemist who studied at Universidad Austral de Chile. I had worked on metabolism, first using a glucose sensor that works by FRET in different cell lines (F. Barros at CECs), and then in the context of sperm cryobiology (A. Ramirez at UACh). This year I have started my PhD in Biomedical Sciences at the University of Chile, I joined SCIAN as a research unit where I´m exploring the dynamics of the endoplasmic reticulum associated with cytoskeleton in calcium homeostasis, combining cell and molecular biology, confocal microscopy and image analysis.

+56 2 2978 6436 ;   Alex Cordova ;  

  Sandra de la Fuente

Masters of Science in Computer Science, University of Chile, Santiago, Chile. Part-time Faculty member in the Department of Computer Science at the University of Chile. My research interests include Medical Informatics, Experts Systems and Informatics and Education. I have professional experience in Clinical Neurophysiology techniques. Currently, I am Project Coordinator for the Medical Informatics Santiago Heidelberg Program.

+56 2 2978 6436 ;   Sandra de la Fuente ;  

  Stefan Sigle

Master of Science in Medical Informatics, currently coordinator in the CHIP - PAGEL project of the DAAD between the University of Heilbronn, University of Chile and the Republic University of Uruguay. Bachelor of Science in Dublin, Ireland. Then student of the Medical informatics programm University of Heidelberg and University of Heilbronn, Germany. As a thesis student elaborating an architectural concept to introduce Whole Slide Imaging to research and Digital Pathology in the clinical environment at the Universidad de Chile. Afterwards working as a research assistant in CPDAI validating image quantification of receptor status in breast cancer. Recently working additionally as lecturer in the master program of Medical Informatics of the Universidad de Chile in the areas of Programming, Human Computer Interaction and Quality Management. Advanced expertise in Business Process Modelling and emerging communication standards in medical technology. Currently pursuing his PhD in Medical Informatics in the area of Resilience and Risk Management of critical systems, partially funded by a Baden-Württemberg scholarship.

+56 2 2978 6266 ;   Stefan Sigle ;  

  Paula Llanos

Paula Llanos was born in Temuco, Chile. She obtained the Bioengineer degree in 2010 and M.Sc on Biochemistry and Bioinformatics in 2012 both from Universidad de Concepción. During her thesis headed by Maria de los Ángeles Garcia, Paula studied glucose sensing mechanism in hypothalamus, specifically how Glucokinase is implicated in the food intake regulation. In 2012, Paula joined Carola Millán laboratory to study how circadian clock is implicated in regulating Glucokinase expression through a genetic approach working also in David Rhoads s Lab at Harvard Medical School, Boston, US. In 2016, Paula became a Biomedical Sciences Ph.D. student and joined SCIAN-Lab to study cytoskeleton dynamics during cellular division through microscopy tools and biophysical approaches. In her current work she works mainly in collaboration with Jacques Dumais from Universidad Adolfo Ibañez and Mauricio Cerda from SCIAN-lab.

+56 2 2978 6266 ;   Paula Llanos ;  

- Masters Students -

  Marcela Aguirre

Physical Therapist, Universidad de Chile, Chile. She was born on 1989 in Santiago, Chile. She obtained her bachelor degree and professional title in Physical Therapy on December 2014. Between February 2015 and August 2017, she worked on a high complexity, public hospital in Santiago (Chile) that specialises in orthopedic pathologies, as a researcher and clinical professional focused on inpatient care. During this period, she also collaborated on research projects related to medical education applied to physical therapy. She is currently in her fourth semester in the master program in Medical Informatics (Universidad de Chile) and her research focuses on the use of machine learning methods in health related issues, currently focused on food patterns and obesity.

;   Marcela Aguirre ;  

- Research Assistants -

  Luis Briones

Bioinformatics Engineer, University of Talca, Chile. His undergraduate thesis work was studying the behavior of phenolate betaine in a poloxamers micellar system through molecular dynamics simulations. He joined SCIAN-Lab as part of the NEMO group. His work will be oriented to complement the communication and visualization of developmental biology phenomenon and applied sciences such as computations and biophysics.

+56 2 2978 6436 ;   Luis Briones ;  

  Alejandra Garcia

Medical Technologist from the University of Chile, where she recently became an MSc student in Biological Sciences. She has worked with different fluorescence related techniques (FRET, FRAP, colocalization analysis and advanced image processing) in cellular and lipid vesicle systems (GUVs). She joined SCIAN in March 2007. She is currently involved in a biomedical research project seeking to investigate the importance of DNA fragmentation for the fertility of sperm samples, using sophisticated mathematical routines for the quantification of fluorescence signals in microscopic images.

+56 2 2978 6266 ;   Alejandra Garcia ;  

  Susana Vargas

Masters in Medical Biophysics, University of Chile, Santiago, Chile. I m currently working at the Centro de Espermiogramas Digitales Asistidos por Internet in the calibration of ED-AI service, most specifically in parameter standardization for image analysis. My interests are in biological/biomedical signal analysis, most of my previous work has been in biosignals (e.g. human electromyographic signals, neural events triggered by visual stimulation in pigeons, human posturographic signals) acquisition and processing, and in software implementations for Digital Signal Acquisition and Processing.

+56 2 2978 6266 ;   Susana Vargas ;  

  Nestor Sepúlveda

B.S and Master degree in Physics in 2004, Universidad de Chile, Santiago, Chile. Phd in Physics in 2009, École Normale Supérieure Paris, France. I am currently interested in obtaining a better understanding and description of cell motion. That is essential for a range physiological and pathological processes such a embryonic morphogenesis, wound healing and cancer metastasis. The team of Miguel Concha has created an experimental set-up that allows the monitoring of cells of an egg of an annual fish. The objective of my project is to develop theoretical models of cell motion to describe the experimental data and propose new experiments based on the predictions of the model.

+56 2 2978 6266 ;   Nestor Sepúlveda ;  

  Juan E. Rodriguez

Juan Eduardo Rodríguez was born in Talcahuano, Chile. He studied Electronic Engineer at University of Concepción, Concepción, Chile, and obtained his BSc. and engineer degree in 2011. He previously worked in electronic circuit design based on microcontrollers at E2i Ltda and at the Center of Optics and Photonics (CEFOP) - University of Concepción. In 2014 he obtained his MSc. in Electrical Engineering at University of Concepción, Chile, thanks to his CONICYT Scholarship. The main topic of his thesis was the development of algorithm for the segmentation of neronal processes in high resolution electron microscopy images. I joined SCIAN lab in April/2015 as Research Assistant. My current interest is in image processing algorithms, design & implementation of electronic circuits, within the context of biomedical engineering.

+56 2 2978 6266 ;   Juan E. Rodriguez ;  

  Marilyn Gatica

Marilyn Gatica was born in 1987 in Santiago, Chile. She obtained the bachelor's degree in Mathematics in 2013 and the professional degree of Mathematical Engineering in 2014 from Universidad de Santiago de Chile. Her undergraduate thesis was supervised by Patricio Orio (CINV) and partially supported by an Anillo project. The main topic of this work was to study spontaneous slow oscillations in the membrane potential by adding noise in the Huber-Braun model. Between June 2015 and February 2016, she was invited by Jesús Cortés to research on community detection by using matrix correlations at BioCruces Health Research Institute, Barakaldo, Basque Country, Spain. Since April 2016 she joined Scian-Lab as part of Anillo VisualD project. Currently, her work is oriented to image processing and software implementation in developmental biology.

+56 2 2978 6266 ;   Marilyn Gatica ;  

  Malcolm Moreno

Born in London England, secondary school teacher at the Universidad Metropolitana de Ciencia de la Educación U.M.CE, Santiago Chile. RedHat Linux Certified Engineer RHCE, with more than 15 year experience in ICT, specially focused in the use of free software to implement educational platforms. Freelance sysadmin for NGOs, educational institutions in Chile and England. Currently he supports de e-learning activities of the Medical Informatics Master Program and he is sysadmin of SCIAN-Lab.

+56 9 6120 6629 ;   Malcolm Moreno ;  

  Jorge Mansilla

Bioinformatic Engineering, Universidad de Talca, Chile. He was born on 1984 in Linares, Chile. He obtained his grade on 2011. That same year, he get into to Scian-Lab (laboratory for Scientific Image Analysis), as a sysadmin. Then on 2012 is invited to integrate a international proyect called "Molecular Profiling of Stage II and III Breast Cancer in Latin American Women receiving Standard of Care Treatment", under the National Cancer Institute from United States, as a sysadmin, support and training on informatics issues to the Centers of Chile. He is member of team U-Redes, this project wants create a 10 Gb interconection between certain educational chilean institutions. Recently he started a master program on medical Informatic, on University of Chile, Chile.

+56 2 2978 6436 ;   Jorge Mansilla ;  

  Jimena López

Engineer, Universidad Privada del Valle, Cochabamba, Bolivia. She was Born on Cochabamba, Bolivia. Business Practice at bioengineering service Hospital Obrero No2 Caja Nacional de Salud Cochabamba , personal technical support at maintenance department of medical device in the company Leonis Home Medic, personal technical services, medical device management, installation, applications, projects of medical equipment and laboratory, company Intersanitas S.R.L. (La Paz Bolivia), Biomedical Engineer at Centro de Salud Tiraque Cochabamba. Currently pursuing the master s program in medical informatics at the University of Chile, and recently working part-time on the project of Digital microscopy as support staff in the evaluation of the Software offered by Visiopharm company in the analysis and quantification of digital images.

+56 2 2978 6266 ;   Jimena López ;  

- Common Members with LEO Lab -

- Associated Members from LEO-Lab -

  Carmen Lemus

Bachelor in Biology from the Catholic University of Chile. She joined LEO in May 2004 as a Research Assistant and then became a PhD student in Biomedical Sciences at the Faculty of Medicine, University of Chile (2008). She holds a CONICYT PhD Scholarship. Her fields of expertise are zebrafish, developmental biology, morphogenesis and 4D confocal imaging. She is currently studying asymmetric morphogenesis of the parapineal organ in the embryonic zebrafish brain. She applies a 3D morpho-topological approach developed at the interphase of biological and mathematical/physical disciplines in the context of a Mutual Enhancement Collaborative Relationship between LEO and SCIAN.

+56 2 2978 6365 ;   Carmen Lemus ;  

- Visitors and Exchange Students -

  Victoria Iribarnegaray

Born in 1989 in Uruguay. She obtained her bachelor's degree in Biology in the field of microbiology, in the Faculty of Science at Udelar, Uruguay. In 2017 she obtained her Master degree in Microbiology supervised by Dr. Paola Scavone at Instituto de Investigaciones Biologicas Clemente Estable, Uruguay. Her thesis was centered on the evaluation of different bacterial factors in Proteus mirabilis biofilm formation. During her thesis, she employed molecular biology approaches, confocal microscopy, image processing to analyze and compare the behavior of different mutant strains during biofilm development. In 2017 she recieved a fellowship founded by UNU-Biolac to do a internship in Scian-Lab during 10 weeks. Her project was based on determining the effect of copper on the biofilms formation of pathogenic bacteria.

;   Victoria Iribarnegaray ;  

- Administrative Staff -

  Martin Pinuer

Audit Accountant, my job is financial accounting administration of scientific research projects, involving administration of the Laboratory for Scientific Image Analysis (SCIAN-Lab) and Digital Semen Analysis Assisted by Internet (CEDAI Spa). I also collaborate as assistant of the Dr. Steffen Härtel, Associate Professor of the Faculty of Medicine, University of Chile and from March 2013 I am working as Clinical studies administrator in Chilean cooperative oncological investigation group (GOCCHI).

+56 2 2978 6266 ;   Martin Pinuer ;  

- Former Members -

Daniela Flores
Maitê Dahdal
Natalia Castro.
Omar Ramírez
Erika Labbe
Ricardo Rivera
Fujan Nuryan D.
Paola Scavone
Ivan Rojas
Pamela Webber
Patrick Werner
Germán Fernández
Jarno Ralli
Camila Saez
José Delpiano
María Osorio-Reich
Nohema Contreras
Pablo Aguilar
Nadia Rojas
Liliana Alcayaga
Jan Scheer
Hector Moraga
Juan Pablo Vivar
Carolina Figueroa
Diego Candia
Felipe de la Fuente

Universidad de Chile Conicyt Xperts Explora Centro de Estudios Científicos